Radiological and surgical aspects of polymorphous low-grade neuroepithelial tumor of the young (PLNTY)

Background: Polymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a low-grade epilepsy-associated tumor recently introduced in WHO 2021 classification. Since it has been recognized as an independent nosological entity, PLNTY has been mainly studied from a genetic and molecular perspective, not recognizing unique characteristic clinical and radiological features. Methods: A systematic literature research has been conducted aiming to identify all relevant studies about the radiological, clinical and surgical features of PLNTY. We described a representative case of a 45-year-old man treated with awake-surgery with confirmed diagnosis of PLNTY, reporting the radiological and surgical characteristics through imaging and intra-operative video. We performed a statistical meta-analysis attempting to assess the presence of relationships between surgical and radiologic tumor characteristics and clinical outcome and type of surgery. Results: A total of 16 studies were included in the systematic review. The final cohort was composed of 51 patients. Extent of resection (EOR) and outcome are not significantly associated with the different genetic profiling (p = 1), the presence of cystic intralesional component, calcification (p = 0.85), contrast-enhancing and lesion boundaries (p = 0.82). No significant correlation there is between EOR and remission or better control of epilepsy-related symptoms (p = 0.38). The contrast enhancement in the tumor is significantly associated with recurrence or poor control of epileptic symptoms (p = 0.07). Conclusions: In PLNTYs, contrast enhancement seems to impact prognosis, recurrence, and seizure control much more than radiological features, genetic features and type of resection of the tumor

Experimental evidence of planar channeling in a periodically bent crystal

The usage of a Crystalline Undulator (CU) has been identified as a promising solution for generating powerful and monochromatic $\gamma$-rays. A CU was fabricated at SSL through the grooving method, i.e., by the manufacturing of a series of periodical grooves on the major surfaces of a crystal. The CU was extensively characterized both morphologically via optical interferometry at SSL and structurally via X-ray diffraction at ESRF. Then, it was finally tested for channeling with a 400 GeV/c proton beam at CERN. The experimental results were compared to Monte Carlo simulations. Evidence of planar channeling in the CU was firmly observed. Finally, the emission spectrum of the positron beam interacting with the CU was simulated for possible usage in currently existing facilities

A compact light readout system for longitudinally segmented shashlik calorimeters

The longitudinal segmentation of shashlik calorimeters is challenged by dead zones and non-uniformities introduced by the light collection and readout system. This limitation can be overcome by direct fiber-photosensor coupling, avoiding routing and bundling of the wavelength shifter fibers and embedding ultra-compact photosensors (SiPMs) in the bulk of the calorimeter. We present the first experimental test of this readout scheme performed at the CERN PS-T9 beamline in 2015 with negative particles in the 1-5~GeV energy range. In this paper, we demonstrate that the scheme does not compromise the energy resolution and linearity compared with standard light collection and readout systems. In addition, we study the performance of the calorimeter for partially contained charged hadrons to assess the $e/\pi$ separation capability and the response of the photosensors to direct ionization.Comment: To appear in Nuclear Instruments and Methods in Physics Research,

Testosterone decreases adiponectin levels in female to male transsexuals

Aim: To evaluate the effect of testosterone (T) on adiponectin serum levels in transsexual female patients. Methods: We measured adiponectin, leptin, luteinizing hormone and follicle stimulating hormone, T, estradiol, lipid profile, biochemical parameters and body composition in 16 transsexual female patients at baseline and after 6 months of T treatment (100 mg Testoviron Depot /10 days, i.m.). Results: Adiponectin levels were 16.9 ± 7.3 mg/mL at baseline and 13.5 ± 7.4 mg/mL at month 6 of T treatment (P < 0.05). Leptin and high-density lipoprotein cholesterol decreased significantly, whereas body mass index, waist circumference and lean body mass increased significantly after 6 months of T treatment. No changes in insulin or Homeostasis Model Assessment were detected. Conclusion: T can significantly reduce adiponectin serum levels in transsexual female patients

Steering efficiency of a ultrarelativistic proton beam in a thin bent crystal

Crystals with small thickness along the beam exhibit top performance for steering particle beams through planar channeling. For such crystals, the effect of nuclear dechanneling plays an important role because it affects their efficiency. We addressed the problem through experimental work carried out with 400 GeV/c protons at fixed-target facilities of CERN-SPS. The dependence of efficiency vs. curvature radius has been investigated and compared favourably to the results of modeling. A realistic estimate of the performance of a crystal designed for LHC energy including nuclear dechanneling has been achieved

Perceived health and its relation with macrosocial and individual factors in children from two departments of Tucumán, Argentina

Introducción: El estudio de la calidad de vida relacionada con la salud (CVRS) durante la infancia permite identificar factores que condicionan el crecimiento y el desarrollo. Los objetivos de este trabajo fueron: a) describir la CVRS de niños con edades comprendidas entre 8,0 y 11,9 años que residían en la provincia de Tucumán; y b) analizar si la CVRS variaba en relación con factores macrosociales (calidad de vida departamental, residencia urbano-rural, nivel socioeconómico) e individuales (edad y sexo). Población y métodos: Estudio cuantitativo, transversal en escolares de los departamentos de Yerba Buena y Simoca. Se aplicó el cuestionario KIDSCREEN-52 para medir dimensiones de CVRS y las pruebas t de Student, análisis de la varianza y regresión logística multivariada para el análisis según factores macrosociales e individuales. Resultados: Se analizaron 1647 encuestas. Los escolares de menor edad y los varones, en general, tuvieron una mejor percepción de su salud. Los residentes en Yerba Buena presentaron puntuaciones medias significativamente más bajas en la dimensión recursos económicos, comparados con los de Simoca (45,3 vs. 46,7, p: 0,01). No hubo asociación entre el nivel socioeconómico y la CVRS. Los niños rurales puntuaron más bajo en la mayoría de las dimensiones, con diferencias significativas en autopercepción (51,3 vs. 53,0, p: 0,01) y estado de ánimo (43,2 vs. 44,5, p: 0,03). Conclusiones: La salud percibida de los niños de Yerba Buena y Simoca varió en relación a aspectos macrosociales e individuales. En Yerba Buena, la percepción de los recursos económicos fue peor respecto de Simoca. En general, las apreciaciones de los niños urbanos fueron más favorables que las de los rurales. Los varones y los escolares de menor edad percibieron mejor su salud.Facultad de Ciencias VeterinariasInstituto de Genética Veterinari